In past decades, nanomedicine
made impressive progress from basic science to clinical application. The goalof nanoparticles in nanomedicine is to develop systems capable of carrying,
releasing and delivering their payload drugs in an efficient manner to target
tissues.
 |
| pH-Sensitive Nanoparticles |
Despite the important
advances in nanotechnology and nanomedicine, these technological translations
for new pharmaceutical products did not meet the expectations of the scientific
community. The gap between the promising in vivo pre-clinical results and the
outcome of clinical trials was not closed, and this continues to challenge
researchers worldwide. As described previously in 2012 nanoparticles with sizes
ranging from 30 nm to 200 nm can be specifically taken up by tumor tissues.
This is a classical phenomenon, well known as the enhanced permeability and
retention (EPR) effect.
No comments:
Post a Comment