pH-Sensitive Nanoparticles for Cancer Therapy: Is this a Real Innovation in Nanomedicine?

In past decades, nanomedicine made impressive progress from basic science to clinical application. The goal of nanoparticles in nanomedicine is to develop systemscapable of carrying, releasing and delivering their payload drugs in an efficient manner to target tissues.

Nanomedicine

Despite the important advances in nanotechnology and nanomedicine, these technological translations for new pharmaceutical products did not meet the expectations of the scientific community. The gap between the promising in vivo pre-clinical results and the outcome of clinical trials was not closed, and this continues to challenge researchers worldwide. As described previously in 2012 nanoparticles with sizes ranging from 30 nm to 200 nm can be specifically taken up by tumor tissues. This is a classical phenomenon, well known as the enhanced permeability and retention (EPR) effect. Read more>>>>>>